Adrenomyeloneuropathy

Adrenomyeloneuropathy is the most common type of X-ALD and is milder compared to Childhood Cerebral ALD. AMN patients usually develop symptoms between the ages of 21 and 35, and AMN develops in almost all X-ALD cases that survive to adulthood. Symptoms include:

•  gradual stiffness 
• paralysis of the lower limbs  
• ataxia (inability to coordinate voluntary muscular movements) 

Many AMN patients have some degree of gait disturbance because both the spinal cord and peripheral nerves to their muscles are affected by this disease. Adrenomyeloneuropathy patients eventually become wheelchair-bound, and the majority also develop adrenal insufficiency (sometimes called Addison's disease). Unless a person with AMN starts to have cerebral demyelination, they have a normal life expectancy.

Normal brain

ALD brain