Female Carriers

About 50% of female adrenoleukodystrophy carriers experience milder variations of symptoms around middle age or later. The reason this occurs has not been well studied. Symptoms that are displayed in these carrier women include progressive stiffness, paralysis of the legs, ataxia, increased muscle tone, moderate peripheral neuropathy, urinary problems, and spastic paraparesis. 
It is rare for carriers to have either cerebral involvement or adrenal dysfunction.